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Updated: Sep 16, 2025

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
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通过诱导核应激和线粒体功能障碍,FTO抑制抑制B细胞急性淋巴细胞白血病的进展

Xinxin Li1, Ziyan Yang2, Siyong Huang3

  • 1Institute of Medical Research, Northwestern Polytechnical University, Xi'an, 710114, China; Shenzhen Research Institute of Northwestern Polytechnical University, Shenzhen, 5180057, China.

Free radical biology & medicine
|July 7, 2025
PubMed
概括

脂肪质量和与肥胖相关的蛋白质 (FTO) 通过调节核糖体生物生成来促进B细胞急性淋巴细胞白血病 (B-ALL). 用多克索鲁比辛准FTO为B-ALL提供了一个潜在的治疗策略,抑制癌症的进展.

关键词:
B-ALL,所有的人.在 FTO FTO FTO.线粒体功能障碍 线粒体功能障碍核状应激压力 核状应激压力核糖体生物生成 (Ribosome biogenesis) 是一种发生在核糖体中的过程.

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