侧隔膜激活作为一个中心枢纽,用于逆转慢性压力诱导的新奇性回避
Chih-Hua Chang1, Sheng-Feng Sung2, Chi-Sheng Chen3
1Division of Neurology, Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City, Taiwan.
概括
慢性压力会通过改变大脑活动来影响寻求新奇的行为. 在小鼠中激活侧隔膜 (LS) 恢复了这种行为,表明它是应激相关疾病的治疗点.
科学领域:
- 神经科学是一个神经科学.
- 行为生物学 行为生物学
- 压力研究 压力研究
背景情况:
- 慢性压力是精神健康障碍 (如抑郁症) 的重要危险因素.
- 压力引起的行为变化包括减少探索和寻找新奇事物.
- 了解这些缺陷的神经生物学基础对于开发有效的治疗方法至关重要.
研究的目的:
- 为了研究潜在的神经机制慢性压力诱导的赤字在寻求新奇的行为.
- 为了确定特定的大脑区域和途径参与调节在压力下的探索性行为.
- 探索针对这些途径进行治疗干预的潜力.
主要方法:
- 使用了一种慢性不可预测压力 (CUS) 鼠标模型.
- 使用Y-迷宫和对象位置任务评估寻找新奇的行为.
- 采用化学遗传学来操纵背部海马体,腹膜区域 (VTA) 和侧隔膜 (LS) 中的神经元活动.
- 使用c-Fos表达来测量神经元活动.
主要成果:
- CUS小鼠表现出减少寻找新奇的行为和减少背部海马活动.
- 背部海马体的化学遗传激活,但不是腹部海马体,恢复了新奇的寻找.
- 在CUS小鼠中,VTA的激活增加了LS活动,并减轻了新奇性回避.
- 选择性激活背部海马和VTA投射LS通路,挽救了寻求新奇的行为.
结论:
- 背部海马在寻找新奇的行为中起着关键的,空间特定的作用.
- 侧隔膜 (LS) 作为一个关键的整合枢纽,从背部海马和VTA接收输入.
- LS激活在抵消慢性压力诱导的新奇回避方面是至关重要的,为与压力相关的疾病提供了潜在的治疗目标.
更多相关视频
相关概念视频
Physiological Foundation of Stress
164
Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Role of the Sympathetic Nervous System
Adrenaline triggers the...
164
Psychological Responses to Stress
103
Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
103
Sympathetic Activation
5.7K
The sympathetic division can influence tissues and organs by releasing norepinephrine at peripheral synapses and distributing epinephrine and norepinephrine through the bloodstream. In times of crisis or stress, sympathetic activation occurs, which is regulated by sympathetic centers in the hypothalamus. As a result, sympathetic activation prepares the body for physical exertion, rapid ATP production, and heightened alertness, allowing individuals to respond effectively to challenging or...
5.7K
Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla
1.5K
The sympathetic pathways of the collateral ganglia and adrenal medulla serve unique but interconnected roles in the sympathetic response.
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
1.5K
Stress Response System
207
The stress response system, also known as the fight-or-flight response, is the body's automatic physiological reaction to perceived threats. Hans Selye introduced the concept of General Adaptation Syndrome (GAS) to describe the predictable pattern of changes that occur in response to stress. GAS consists of three sequential stages: alarm, resistance, and exhaustion. This model helps explain how chronic stress can contribute to health problems.
Alarm stage
In the alarm stage, the body's...
Alarm stage
In the alarm stage, the body's...
207
Hypothalamic-Pituitary Axis
61.8K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
61.8K


