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癌症治疗方面的创新:用芯片实验室技术评估耐药性

Parisa Heydari¹, Pouya Javaherchi², Meisam Samadzadeh³

¹Department of Research Analytics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India; Department of Biomaterials and Tissue Engineering, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

International journal of pharmaceutics

|July 7, 2025

概括

实验室芯片 (LoC) 技术提供先进的癌症药物耐药性评估,但在复制瘤微环境和标准化方面面临挑战. 未来与AI和omics的整合有望实现个性化癌症治疗.

科学领域:

生物技术是生物技术.
癌症研究癌症研究
微流体学微流体学

背景情况:

实验室芯片 (LoC) 技术正在通过实现高通量查和实时监测细胞对药物反应来彻底改变癌症研究.
耐药性仍然是癌症治疗的一个主要障碍,需要创新的研究工具.

研究的目的:

审查LoC技术在推进癌症治疗范式中的挑战和未来前景.
突出LoC系统在了解瘤微环境 (TME) 和促进个性化医疗方面的潜力.
确定临床环境中采用LoC的关键障碍,包括模型复杂性和标准化.

主要方法:

对癌症研究中LoC技术的当前文献的综述.
分析复制瘤微环境 (TME) 和确保标准化的挑战.
探索新兴技术,如3D生物打印,奥米克,人工智能和纳米技术,以促进LoC的发展.

主要成果:

LoC平台有助于高通量查和实时监测癌症药物耐药性.
挑战包括精确建模TME,标准化,高成本和临床翻译.
未来的前景包括整合3D生物打印,患者衍生瘤球体 (PDTS),奥米克,人工智能和纳米技术.

结论:

对于个性化癌症治疗和了解耐药性而言,LoC技术具有显著的前景.
克服TME建模,标准化和成本方面的挑战对于广泛的临床采用至关重要.
互补技术的进步将加速将LOC纳入制药开发和临床实践.

关键词:

癌症治疗治疗癌症治疗药物耐药性药物耐药性药物耐药性一个芯片上的实验室个性化医疗是个性化的医疗.瘤微环境是一个微环境.

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