以期望为指导:精神分裂症中超重的语义先验及其与谷氨酸的联系
Franziska Knolle1, Elisabeth F Sterner1, Verena F Demler1
1School of Medicine and Health, Department of Diagnostic and Interventional Neuroradiology, Technical University of Munich, Munich, Germany; School of Medicine and Health, TUM-NIC Neuroimaging Center, Technical University of Munich, Munich, Germany.
精神分裂特征的个体在语言处理方面超越了先前的信念,导致幻觉. 这种过度依赖预测与更高的环状氨酸水平有关.
科学领域:
- 认知神经科学是一种认知神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 像幻觉这样的精神病症状与先前的信念和感官证据之间的不平衡有关.
- 精神分裂特征代表了心理病倾向的亚临床形式.
研究的目的:
- 为了研究精神分裂特征的个体如何在语言理解中权衡语义先验与感官证据.
- 为了确定这种权重失衡是否导致基于任务的幻觉.
- 探索这种不平衡与皮质谷氨酸水平之间的联系.
主要方法:
- 一个语言理解任务操纵语义可预测性和感官退化.
- 贝叶斯信念更新模型估计了先前的权重.
- 进行了两项研究:第1项研究 (n=109) 用于行为分析,第2项研究 (n=55) 用于复制和1H磁共振光谱 (MRS) 用于测量谷氨酸.
主要成果:
- 较高的精神分裂与在语言任务中超重的高层次先验相关.
- 这种过度依赖先验解释了精神分裂特征个人的基于任务的幻觉增加.
- 第二项研究复制了这些发现,并将之前的超重与带状谷氨酸增加联系起来.
结论:
- 研究结果表明,人们对改变预测编码如何导致精神病谱症状有机理解.
- 结果为精神分裂症中过度依赖自上而下的预测提供了神经生物学基础.
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