大脑的功能连接调解了童年不良经历和行为问题之间的关联
Panshi Liu1, Donghui Song2, Ying Guo2
1Department of Radiology, First Hospital of Shanxi Medical University, Taiyuan, China; College of Medical Imaging, Shanxi Medical University, Taiyuan, China; State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China; IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
概括
儿童不良经历 (ACE) 与青少年的行为问题 (CP) 有关. 大脑的功能连接部分调解了这种关联,这表明它是早期干预的潜在生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 儿童精神病学 儿童精神病学
背景情况:
- 童年不良经历 (ACE) 是青少年行为问题 (CP) 的重要风险因素.
- 将ACE与CP联系起来的神经生物学途径尚不清楚,特别是大脑功能连接的作用.
研究的目的:
- 调查大脑功能连接是否调解了青少年ACE和CP严重程度之间的关系.
- 确定与CP相关的特定大脑连接,并评估它们的调解作用.
主要方法:
- 在青少年大脑认知发展 (ABCD) 研究中利用了11,868名儿童的数据.
- 采用线性混合效应 (LME) 建模来评估ACE和CP的关联.
- 应用基于连接组的预测建模 (CPM) 来识别和验证与CP相关的大脑连接,通过在四年内进行的调解分析.
主要成果:
- 在总ACE和增加的CP得分 (p<0.01) 之间发现了显著的关联.
- CPM成功预测了CP得分 (ρ=0.128,p<0.001),验证了涉及感官运动,情绪和冲动性处理的连接.
- 功能连接性在基线和后续评估中部分介导了ACE和CP得分之间的联系 (p<0.01).
结论:
- 这项研究提供了第一个证据,证明功能性大脑连接是ACE和随后的行为问题之间的生物学联系.
- ACE似乎改变了这些CP相关连接的强度,从而增加了CP风险.
- 这些发现强调了早期ACE查的重要性,并突出了与CP相关的联系作为干预的潜在生物标志物.
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