微生物组在CAR-T细胞治疗中的作用
Reham Abdel-Wahab1, Travis D Kerr2, Daniel J McGrail2
1Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer, Houston, TX, United States.
International review of cell and molecular biology
|July 7, 2025
概括
化学抗原受体 (CAR) T细胞疗法对血液癌症有希望,但与固体瘤作斗争. 肠道微生物组显著影响CAR-T细胞的有效性,为改善癌症治疗结果提供了新的策略.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 微生物组研究 微生物组研究
背景情况:
- 化学抗原受体 (CAR) T细胞疗法是血液癌症的突破.
- 在固体瘤中,CAR-T细胞疗法面临着挑战,包括有限的疗效和毒性.
- 微生物组在癌症免疫治疗中的作用越来越被认可,但对CAR-T细胞并未完全理解.
研究的目的:
- 审查当前对微生物组-CAR-T细胞相互作用的理解.
- 突出知识差距,即肠道微生物如何影响CAR-T细胞疗法.
- 探索微生物组操纵策略,以增强CAR-T细胞疗法.
主要方法:
- 临床前和临床研究的文献综述.
- 与CAR-T细胞治疗相关的肠道微生物动态的分析.
- 综合当前关于微生物组对CAR-T细胞的作用的知识.
主要成果:
- 微生物群,特别是肠道细菌,影响CAR-T细胞的疗效.
- 特定的微生物成分可能会增强或损害CAR-T细胞的反应.
- 了解这些相互作用对于克服CAR-T治疗的局限性至关重要.
结论:
- 微生物组是影响癌症CAR-T细胞治疗结果的关键因素.
- 准肠道微生物组提供了一个有希望的策略,以提高CAR-T细胞对固体瘤的疗效.
- 需要进一步的研究来阐明精确的机制,并开发临床应用.
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