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Updated: Sep 16, 2025

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
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PD-1表达小岛特异性的CD4+ T细胞促进旁观者耐受性,并防止自身免疫

Jeniffer D Loaiza Naranjo1, Vivian Zhang1, Rathna Ravichandran1

  • 1Frazer Institute, The University of Queensland, Brisbane, QLD, Australia.

Immunology and cell biology
|July 7, 2025
PubMed
概括

对CD4+T细胞的编程死亡1 (PD-1) 对于维持1型糖尿病的自我耐受性至关重要. 它的缺失通过损害自身反应性CD8+T细胞的抑制来加速自身免疫进展.

关键词:
在PD‐1中,这是自身免疫力.监管 监管 监管 监管 监管 监管这是一个宽容的宽容度.第1类糖尿病 1型糖尿病

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