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Updated: Sep 16, 2025

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在骨髓增殖性新生瘤中,JAK2抑制调解了RAS途径突变的克隆选择

Nabih Maslah1,2, Nina Kaci3, Blandine Roux3

  • 1Université Paris Cité, APHP, Hôpital Saint-Louis, Laboratoire de Biologie Cellulaire, Paris, France.

Nature communications
|July 7, 2025
PubMed
概括

像ruxolitinib这样的Janus 激酶 (JAK) 抑制剂可以意外地促进骨髓纤维化患者RAS突变的生长. 这一发现表明,在用于骨髓增殖性瘤 (MPN) 的JAK抑制剂治疗之前,需要对RAS突变进行查.

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