母亲喘与后代的ASD/ADHD之间的关联:基于观察研究的元分析
Jingfang Zheng1, Junyi Chen2, Qiufeng Zhang3
1Department of Obstetrics and Gynaecology, The Affiliated People's Hospital of Ningbo University, 251 Baizhang East Road, Yinzhou District, Ningbo, 315040, Zhejiang, China. zhengjingfang1981@163.com.
母亲喘与儿童患自闭症谱系障碍 (ASD) 和注意力缺陷多动症障碍 (ADHD) 的风险更高有关. 这种关联特别在男性后代中发现ASD,在男性后代中发现ADHD,在男性后代中发现ADHD.
科学领域:
- 儿科流行病学 儿科流行病学
- 神经发育障碍 神经发育障碍
- 呼吸系统医学 呼吸系统医学
背景情况:
- 喘是一种常见的慢性呼吸道疾病,影响全球数百万人.
- 自闭症谱系障碍 (ASD) 和注意力缺陷多动性障碍 (ADHD) 是复杂的神经发育状况.
- 了解潜在的环境风险因素,例如怀孕期间母亲的健康状况,对于早期干预和预防策略至关重要.
研究的目的:
- 进行一项元分析,调查母亲喘与后代ASD或ADHD发病率之间的关联.
- 综合现有队列和病例控制研究的证据,以确定这种关系的强度和方向.
主要方法:
- 在主要数据库 (PubMed,科学网,Embase,Cochrane图书馆) 进行了全面的文献搜索,截至2024年10月.
- 包括的研究将孕产妇喘定义为产前存在的疾病.
- 分析结合了来自5个队列和7个病例控制研究的数据,分析了后代ASD/ADHD发病率的主要结果.
主要成果:
- 与对照人群相比,患有喘的母亲的后代的ASD (OR=1.36) 和ADHD (OR=1.43) 发病率显著更高.
- 亚组分析表明,男性后代的自闭症发病率较高 (OR=1.28) 但女性后代的发病率较高 (OR=1.81,P=0.205).
- 在患有喘母亲的男性 (OR=1.36) 和女性 (OR=1.45) 后代中观察到ADHD发病率升高.
结论:
- 母亲喘与子女患ASD和ADHD的风险增加有关.
- 母亲喘和ASD之间的关联在男性后代中似乎更为强烈.
- 这些发现凸显了考虑孕产妇喘作为神经发育障碍病因的潜在危险因素的重要性.
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