在食道癌症中的托里帕利马布:系统性审查和元分析
Mostafa A Khalifa1, Marafi Jammaa Ahmed2, Hashim Talib Hashim3
1Faculty of Medicine, Cairo University, Cairo, Egypt.
Journal of gastrointestinal cancer
|July 7, 2025
概括
托里帕利马布在食道癌症治疗方面表现有前途,改善了反应和生存率. 由于潜在的副作用和研究局限性,需要进一步研究.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 胃肠病学 胃肠病学
背景情况:
- 食道癌 (EC) 是一种具有不良预后的侵袭性恶性瘤.
- 作为PD-1抑制剂的托里帕利马布 (Toripalimab) 具有改善欧洲共同体临床结果的潜力.
- 本综述评估了Toripalimab在EC治疗中的疗效和安全性.
研究的目的:
- 系统地审查和分析托里帕利马布在食道癌症中的疗效.
- 评估与托里帕利马布治疗相关的安全概况和不良事件.
- 综合关于托里帕利马布用于EC治疗的当前证据.
主要方法:
- 按照PRISMA 2020指南进行系统审查和元分析.
- 搜索了主要的数据库 (PubMed,Embase,Scopus等等) 在2025年1月之前.
- 包括RCT和非RCT,使用随机效应模型分析OS,PFS,ORR和不良事件.
主要成果:
- 对6项研究 (678名患者) 的综合分析显示了有希望的疗效.
- 关键的疗效指标:CR 33%,PR 36%,PCR 30%,MPR 46%,R0切除87%. 这种疗效指标是:
- 常见的不良事件:贫血 (56%),脱发 (54%),白血病 (54%),疲劳 (30%).
结论:
- 托里帕利马布在治疗食道癌症方面具有显著的潜力,具有良好的反应和生存率.
- 副作用的高发病率需要支持性护理和进一步调查.
- 有限的样本大小和潜在的偏差突出了需要更大的随机试验.
相关概念视频
Treatment Resistant Cancers
3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
Esophageal Varices-II: Clinical Features and Management
147
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
147
Barrett Esophagus-II: Clinical Manifestations and Management
315
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
315
Tumor Immunotherapy
665
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
665
Targeted Cancer Therapies
7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.8K


