多重性诱导了老鼠的持续的心肌结构,功能和转录基因重塑
Ruth R Magaye1,2, Bing H Wang1,2,3, Hongyi R Liu1
1Heart Failure Research Group, Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC, 3004, Australia.
Scientific reports
|July 7, 2025
概括
多重怀孕可能会增加心力衰竭的风险,因为它会导致心肌的持久变化. 这项研究发现,多胞胎小鼠表现出持续的心脏重塑和改变的基因表达,这表明与心力衰竭与保留射出分数 (HFpEF) 有关.
科学领域:
- 心脏病学 心脏病学
- 生殖生物学 生殖生物学
- 基因组学就是基因组学.
背景情况:
- 怀孕对心脏造成显著的血液动力学和代谢压力.
- 多重怀孕与晚年心力衰竭的风险增加有关,心力衰竭与保存的喷射分数 (HFpEF) 有关.
- 与HFpEF连接多元化的基本机制在很大程度上是未知的.
研究的目的:
- 调查重复怀孕是否导致持续的心肌重塑.
- 探索多重性诱导的心脏变化与HFpEF发展之间的潜在联系.
- 为了识别与多胎妊娠相关的心脏中的分子和结构变化.
主要方法:
- 多发性 (MP) 和非发性 (NP) 的老鼠的比较 (C57Bl/6J).
- 通过心声学评估心血管参数,包括血压,身体组成,心脏结构和功能.
- 转录组分析 (mRNA水平和RNA测序) 左心室心肌.
主要成果:
- 与NP小鼠相比,MP小鼠表现出心脏与骨长度比率,体重和脂肪质量增加.
- 脑膜异位小鼠显示心脏扩张功能受损 (增加异体度放松时间) 和轻微减少喷射分数.
- 在MP小鼠中观察到心脏标志物mRNA (Myh6,Nppa) 的升高,Il18和纤维素 mRNA的增加,以及显著的间歇性纤维化.
- RNA测序揭示了128个基因的持续差异表达,受影响的途径包括细胞外矩阵调节和有机离子/离子运输.
结论:
- 多样性会导致心脏基因表达和心肌结构的持久变化,这些变化会持续到晚年.
- 这些持续变化为心力衰竭表型的发展提供了潜在的基质,例如HFpEF.
- 需要进一步的研究来阐明与怀孕相关的心脏改造和其他HFpEF风险因素之间的相互作用.
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