介酶干细胞衍生的外体细胞通过抑制低毒性肺高血压的EGFR/ErbB2异体化来改善血管重塑

Yao-Xin Chen1, Zhi-Hua Deng1, Xiao-Wei She2

  • 1Department of Respiratory and Critical Care Medicine, Suzhou Municipal Hospital, Gusu School, The Affiliated Suzhou Hospital of Nanjing Medical University, Nanjing Medical University, Suzhou, 215000, China.

Scientific reports
|July 7, 2025
PubMed
概括

介酶干细胞衍生的外体细胞 (MSC-exo) 在治疗缺氧性肺高血压 (HPH) 中表现有前途. 通过抑制EGFR/ErbB2信号传递,MSC-exo疗法抑制了肺动脉光滑肌细胞的增殖,并减少了大鼠的HPH相关症状.

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