血清度与慢性病患病率之间的关联:来自NHANES 1999-2018年的证据
1Department of Nephrology, Zigong Fourth People's Hospital, 19 Tanmulin Road, Zigong, 643000, Sichuan, China. meilinzgedu@163.com.
Scientific reports
|July 7, 2025
概括
血清度升高与慢性病 (CKD) 的更高患病率有关. 这一发现表明血清度可能是评估CKD风险和改善患者管理的有价值生物标志物.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 生物标志物 生物标志物
- 公共卫生 公共卫生
背景情况:
- 慢性病 (CKD) 是一个主要的全球健康问题.
- 早期识别CKD风险因素对于有效的预防和干预策略至关重要.
- 血清度作为CKD潜在生物标志物的作用需要进一步研究.
研究的目的:
- 调查血清度水平与慢性病 (CKD) 患病率之间的关联.
- 探索血清度和CKD之间的潜在线性和非线性关系.
- 评估这些发现在不同的人口分组中的一致性和适用性.
主要方法:
- 来自国家健康和营养检查调查 (NHANES) 的大型数据集分析,涵盖1999-2018年 (n=49,008).
- 利用多变量逻辑回归和受限立方线 (RCS) 分析来评估相关性.
- 进行了子组和相互作用分析,以检查年龄,性别和高血压等因素的影响.
主要成果:
- 在较高的血清度和增加的CKD患病率之间观察到显著的积极关联,在完全调整后仍然存在 (OR: 1.18).
- 血清度最高四分位数的参与者表现出明显更高的CKD风险 (OR:3.97).
- RCS分析证实了非线性正相关性,对年龄,性别和高血压有显著的相互作用.
结论:
- 血清度与CKD患病率有显著的关联,表明其作为一种有价值的生物标志物的潜力.
- 这些发现为加强CKD风险评估和管理协议提供了新的见解.
- 观察到的关联表明在各种人口和人口统计因素中具有广泛的适用性.
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