肠道微生物组在代谢功能障碍相关的脂肪性肝病和相关的肝细胞癌中
Harry Cheuk-Hay Lau1, Xiang Zhang1, Jun Yu2
1Institute of Digestive Disease, Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China.
Nature reviews. Gastroenterology & hepatology
|July 7, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 与肠道微生物组的变化有关. 准肠道微生物组为MASLD和相关的肝病提供了潜在的治疗策略.
科学领域:
- 胃肠病学和肝病学
- 微生物组研究 微生物组研究
- 代谢疾病 代谢疾病
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个全球性的健康问题,有可能发展为严重的肝病.
- 肠道微生物组在MASLD的发病和进展中发挥着关键作用.
- 新出现的证据支持针对肠道微生物组进行MASLD治疗.
研究的目的:
- 审查MASLD,脂肪肝炎和肝细胞癌中的肠道微生物变化.
- 在MASLD进展中阐明肠肝轴失调的机制.
- 讨论微生物组调制对MASLD的诊断和治疗应用.
主要方法:
- 关于MASLD和肠道微生物组的综合文献综述.
- 分析涉及肠道屏障功能障碍,炎症和改变代谢途径的机制.
- 基于微生物组的诊断生物标志物和治疗策略的评估.
主要成果:
- 在MASLD,脂肪肝炎和肝细胞癌中观察到肠道微生物的改变.
- 肠肝轴的失调涉及肠道屏障受损,炎症和改变的微生物代谢物.
- 便微生物种移植,益生菌,益生菌和微生物代谢物的潜在诊断和治疗作用.
结论:
- 肠道微生物组是MASLD发展和进展的组成部分.
- 调节肠道微生物组为MASLD的诊断和治疗提供了有希望的途径.
- 需要进一步的研究来克服基于微生物的MASLD疗法的挑战.
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