通过NHANESES系统炎症反应指数介导的睡眠障碍和高血压
Zhaoxing Cao1,2, Fangfang Zhuo1,2, Fei Yan1,2
1Department of Cardiovascular Medicine, The Affiliated Hospital of Guizhou Medica University, Guiyang, 550004, China.
Scientific reports
|July 7, 2025
概括
通过系统性免疫炎症指数 (SII) 测量的炎症稍微介导了睡眠障碍和高血压之间的联系,特别是在男性中. 在患有高血压或睡眠障碍的人群中观察到较高的SII水平.
科学领域:
- 心血管健康 心血管健康
- 睡眠医学 睡眠医学
- 免疫学 免疫学 免疫学
背景情况:
- 高血压和睡眠障碍独立地与炎症有关.
- 炎症在连接睡眠障碍和高血压方面的确切作用尚不清楚.
研究的目的:
- 研究一种新的炎症标志物 - - 系统性免疫炎症指数 (SII),睡眠障碍和高血压之间的关联.
- 检查SII在睡眠障碍和高血压之间的关系中的调解作用.
主要方法:
- 来自国家健康和营养检查调查 (NHANES) (2005-2020) 的大量多元种族样本 (n=23,414) 的分析.
- 评估SII,睡眠障碍和高血压之间的对联关系.
- 调解分析以确定SII在睡眠障碍-高血压联系中的作用,按性别分层.
主要成果:
- 与没有高血压和/或睡眠障碍的参与者相比,SII水平较高.
- 在男性中,SII在睡眠障碍和高血压之间表现出轻微但具有统计学意义的调解效应 (PM=1.36%).
- 在女性中没有发现SII的显著调解效应.
结论:
- 系统性免疫炎症指数 (SII),睡眠障碍和高血压是相互关联的.
- 较高的SII水平部分解释了睡眠障碍和高血压之间的关联,特别是在男性中.
- 研究结果强调炎症是将睡眠问题与高血压联系起来的潜在途径.
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