在SCAPIS研究中,肠道微生物组与24小时血压测量之间的联系
Yi-Ting Lin1,2, Sergi Sayols-Baixeras1,3, Gabriel Baldanzi1
1Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Communications medicine
|July 7, 2025
概括
肠道微生物组会影响血压. 下肠道微生物群的多样性与更高的血压变化有关,特定的肠道细菌与24小时的血压特征有关.
科学领域:
- 微生物组研究的研究.
- 心血管健康的心血管健康
- 代谢学 代谢学 代谢学
背景情况:
- 越来越多的证据将肠道微生物群与高血压联系起来.
- 以前的研究表明,肠道微生物群在血压调节中的作用.
研究的目的:
- 调查肠道微生物特征与24小时门诊血压之间的关联.
- 为了确定与血压特征相关的特定微生物物种和功能.
主要方法:
- 从3695名参与者的便样本中进行了枪支元基因组测序.
- 对24小时门诊血压和办公室血压测量的分析.
- 用多变量调整的模型来评估没有抗高血压药物的参与者的关联.
主要成果:
- 肠道微生物组的α多样性与静脉血压变化有负相关性.
- 四种特定的肠道微生物物种 (Streptococcus sp001556435,Intestinimonas massiliensis,Dysosmobacter sp001916835,ER4 sp900317525) 与24小时的血压特征有关.
- 关联在办公室血压数据中得到复制,相关的微生物物种显示出类似的代谢物模式.
结论:
- 肠道微生物群的α多样性与静脉血压的变化相反.
- 特定的肠道微生物种与24小时血压特征有关,突出了高血压管理的潜在目标.
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