认知灵活性与1型糖尿病患者的发病年龄和持续时间有关
Ding Mojun1,2,3,4, Yuan Dongling1,2,3,4, He Jing5
1Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Scientific reports
|July 7, 2025
概括
1型糖尿病会影响认知灵活性,记忆力和注意力. 早期发病年龄和较长的糖尿病持续时间显著影响认知功能,特别是在儿童发病的情况下.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 心理学 心理学 心理学
背景情况:
- 认知障碍是1型糖尿病 (T1D) 的已知风险.
- 导致T1D认知衰退的因素尚未完全理解.
- 受影响的特定认知领域及其与临床因素的关系需要进一步调查.
研究的目的:
- 研究认知功能 (记忆,注意力,认知灵活性) 与T1D的临床/血糖因素之间的关系.
- 探索发病年龄和糖尿病持续时间如何影响认知表现.
- 为了比较成人发病和儿童发病T1D组之间的认知网络结构.
主要方法:
- 在331名T1D患者的认知功能和临床特征的网络分析.
- 使用韦克斯勒记忆量表,威斯康星州卡片排序测试和持续关注响应任务的认知评估.
- 临床因素的评估:发病年龄,糖尿病持续时间,血糖控制和极端的血糖事件.
主要成果:
- 发病年龄和糖尿病持续时间是影响认知灵活性的中心节点.
- 发病年龄与严重低血糖病史相关;糖尿病持续时间与视觉记忆力下降有关.
- 与成人发病相比,儿童发病的T1D组在认知网络中表现出更大的相互联系.
结论:
- 发病年龄和疾病持续时间对1型糖尿病的认知结果产生重大影响.
- 独特的网络结构表明基于T1D发病年龄的不同认知轨迹.
- 进一步的纵向研究至关重要,以指导在T1D中维护认知功能的干预措施.
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