经过急性胰腺炎的长期生活质量:系统性审查和元分析
Dongming Xu1, Chang Liu2, Jie Zhou2
1Department of Emergency Medicine, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong-an Road, Xicheng District, Beijing, 100050, China. xdm8211@sina.com.
BMC gastroenterology
|July 7, 2025
概括
患有急性胰腺炎 (AP) 的患者经历长期生活质量 (QoL) 损害,特别是在疼痛和心理健康领域. 身体功能仍然相对保持良好,这表明需要有针对性的QoL评估.
科学领域:
- 胃肠病学和肝病学
- 临床结果研究研究
背景情况:
- 急性胰腺炎 (AP) 对患者的生活质量 (QoL) 的长期影响尚未得到充分证实.
- 现有的研究对AP后的QoL提出了不确定的发现.
研究的目的:
- 系统地审查和分析急性胰腺炎后患者的长期 QoL 结果.
- 为了比较AP幸存者和健康个体之间的QoL.
主要方法:
- 在主要数据库 (PubMed,EMBASE,Web of Science等) 中进行了全面的文献搜索. 在2025年4月之前.
- 包括11项涉及2541名参与者的研究,比较使用SF-36和SF-12领域的QoL.
- 计算了聚合平均差异和置信区间;评估了异质性和出版偏差.
主要成果:
- 与对照组相比,AP患者在身体疼痛,一般健康,活力,角色情绪和心理健康领域报告了显著较低的QoL.
- 在身体功能,角色身体,社会功能或SF-12总结分数方面没有发现显著差异.
- 敏感性分析将单一研究确定为异质性的来源;没有发现显著的出版偏差.
结论:
- 患有AP病史的个人在特定领域,特别是疼痛和心理健康方面,表现出持续的QoL缺陷.
- 身体功能和QOL的社会方面似乎相对不受影响.
- 对于胰腺疾病,有必要开发特定疾病的 QoL 评估工具.
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