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多维睡眠健康和痴呆风险:英国生物银行的一项前性研究
Tianyi Huang1, May A Beydoun2, Sina Kianersi3
1Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute On Aging, Baltimore, MD, USA. tianyi.huang@nih.gov.
BMC medicine
|July 7, 2025
概括
睡眠不良显著增加了痴呆症的风险,特别是血管痴呆症. 识别特定的睡眠模式可以帮助针对高风险个体的干预措施.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 睡眠障碍与影响痴呆风险的各种病原性途径有关.
- 关于多维睡眠健康和痴呆症的研究有限,特别是关于痴呆症亚型的研究.
研究的目的:
- 调查多维睡眠健康与所有原因痴呆症,血管痴呆症 (VaD) 和阿尔茨海默病 (AD) 风险之间的关联.
- 探索不同睡眠健康模式之间痴呆风险的潜在异质性.
主要方法:
- 利用了来自313,248名没有痴呆症的参与者 (年龄≥50岁) 的英国生物库数据.
- 通过睡眠健康评分 (SHS) 和七个自我报告因素的潜在类分析,评估了多维睡眠健康.
- 采用Cox的比例风险模型来分析与事件痴呆症的关联,平均随访时间为12年.
主要成果:
- 较高的SHS (更好的睡眠) 与较低的痴呆风险有关 (HR为所有原因痴呆的0.57,比较最佳与最差的睡眠).
- 确定了六种不同的睡眠模式,其中五种与所有原因痴呆风险增加 (8-85%) 相关,四种与VaD风险增加 (11-148%) 相关.
- 严重睡眠障碍是唯一与AD风险增加 (56%) 显著相关的模式.
结论:
- 不良的多维睡眠健康,无论是通过SHS还是不同的模式来衡量,都与痴呆症风险增加有关.
- 睡眠模式与不同痴呆症亚型的关系存在显著的异质性.
- 描述睡眠状况可以帮助识别有风险的人群,并制定有针对性的痴呆症预防策略.
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