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肠道微生物组成与高血压老年患者的饮食模式之间的关联:一个横截面研究
Hsi-Cheng Hung1,2, Yuan-Yuan Lin3, Wan-Jung Tien3
1School of Nutrition and Health Sciences, Taipei Medical University, Taipei, 11031, Taiwan.
Nutrition & metabolism
|July 7, 2025
概括
高血压的老年人表现出改变的肠道微生物群,其中包括较低的Bacteroides caccae和Barnesiella. 减少 Bacteroides caccae 与摄入和脂肪和的增加有关,突出显示饮食.
科学领域:
- 微生物组研究的研究.
- 老年医学 老年医学
- 心血管健康的心血管健康
背景情况:
- 对老年人肠道微生物群,饮食和高血压的研究有限.
- 缺乏对详细的饮食模式和饮食习惯的关注.
- 这项研究解决了对高血压老年人肠道微生物群的理解上的差距.
研究的目的:
- 为了研究高血压老年人的肠道微生物群概况.
- 检查饮食模式,营养摄入量和肠道微生物群之间的关系.
- 在这个人口群体中确定与高血压相关的特定微生物变化.
主要方法:
- 一项涉及20名高血压患者和21名健康对照组 (65-80岁) 的横截面研究.
- 数据收集包括人体测量,血压,生化分析和详细的饮食评估 (24小时回忆,食物频率问卷).
- 使用16S rRNA测序分析了便微生物群组成.
主要成果:
- 高血压患者的BMI,腰围和缩血压都较高.
- 在肠道微生物群中存在显著差异:较低的Bacteroides caccae和Barnesiella;较高的Enterobacteriaceae,Enterobacter,Acidaminococcus和Bacteroides plebeius.
- 细菌的丰富度与和脂肪,,主食,坚果油和调味料摄入量有负相关性.
结论:
- 与对照人群相比,高血压的老年人表现出明显的肠道微生物群概况.
- 观察到较低水平的Bacteroides caccae和Barnesiella,以及较高的与Enterobacteriaceae相关的种类.
- 饮食因素,特别是和脂肪和,与肠道微生物群组成有关,可能会影响高血压.
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