围产期风险因素对儿科喘的影响:系统性审查和元分析
Naixu Liu1, Yali Ding1, Chanchan Hu1
1From the Department of Pediatrics, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Allergy and asthma proceedings
|July 8, 2025
概括
孕产妇吸烟,早产,孕产妇喘病史和围产期使用抗生素是儿童喘的主要危险因素. 在产前期的意识和有针对性的干预对于预防至关重要.
科学领域:
- 儿科呼吸系统医学 儿科呼吸系统医学
- 围产期健康 围产期健康
- 流行病学 流行病学
背景情况:
- 儿童喘严重影响儿童的健康和家庭的财务状况.
- 孕产妇的围产因素对儿科喘的发展和严重程度至关重要.
- 对围产期风险因素的有限认识有助于喘患病率的上升.
研究的目的:
- 系统地审查和元分析影响儿科喘 (PA) 的围产期风险因素.
- 为改善儿童喘周产期管理和预防策略提供证据.
主要方法:
- 按照PRISMA指南进行系统审查和元分析.
- 观察性研究的回顾性搜索至2024年4月24日.
- 使用基于科克兰Q测试和I2统计数据的随机或固定效应模型进行元分析.
主要成果:
- 包括26项观察性研究,涉及2,143,844名参与者.
- 确定了重要的危险因素:孕妇周产期吸烟 (OR 1.11),早产<37周 (OR 1.50),孕妇喘史 (OR 1.80) 和孕妇周产期使用抗生素 (OR 1.82).
- 多变量分析证实母亲吸烟 (OR 1.83) 和母亲喘史 (OR 4.49) 是关键风险.
结论:
- 孕产妇吸烟,早产 (<37周),孕产妇喘病史和围产期使用抗生素是儿童喘的确诊危险因素.
- 针对这些围产期因素的有针对性的干预措施是必要的,以减轻儿童喘的风险.
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