母亲酸盐补充剂改善了肥胖怀孕中的后代心脏代谢结果
Kristi M Crowe-White1, Katelyn E Senkus1,2, Janie C DiNatale1
1Department of Human Nutrition, The University of Alabama, Tuscaloosa, AL, USA.
Annals of medicine
|July 8, 2025
概括
孕妇在怀孕期间食用酸盐补充剂改善了后代的心脏代谢健康,降低了体重,腹周和葡萄糖水平. 这表明酸盐对肥胖母亲产生的后代的胎儿发育和能量代谢有积极的影响.
科学领域:
- 生殖生物学 生殖生物学
- 代谢健康 代谢健康
- 营养科学 营养科学
背景情况:
- 怀孕期间的孕产妇肥胖与由于胎儿编程而导致后代的不良心脏代谢结果有关.
- 饮食中酸盐对心脏代谢健康的益处已知,但其对肥胖母亲的后代的影响尚不清楚.
研究的目的:
- 为了研究母体食无机酸盐补充剂对高脂肪饮食 (HFD) 的斯普拉格-道利大鼠后代心脏代谢健康的影响.
主要方法:
- 雌性大鼠被食正常脂肪饮食 (NFD) 或高脂肪饮食. 肥胖的HFD大鼠接受了无机酸盐 (HFDN). 对后代进行了身体组成,体重,腹周和心脏代谢生物标志物的评估.
- 关键生物标志物包括葡萄糖,胰岛素,脂质和棕色脂肪组织 (BAT) 中的F1Fo ATP合成酶c亚单元蛋白水平.
主要成果:
- 与NFD和HFDN组相比,来自HFD母的后代的体重和腹周长都更高.
- HFDN后代的葡萄糖和甘油三水平显著降低,并在BAT中恢复了F1Fo ATP合成酶c子单元蛋白.
- 母亲补充酸盐改善了后代的体重,腹周,葡萄糖和脂质状况.
结论:
- 孕期和产前酸盐补充剂可能为超重或肥胖怀孕的后代提供保护性心脏代谢益处.
- 母亲的酸盐摄入量似乎影响胎儿的发育,并通过细胞反应调节后代的能量代谢.
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