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Emel Tekin¹, Damla Oflas², Bartu Badak³

¹Department of Pathology, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey.

Indian journal of pathology & microbiology

|July 8, 2025

概括

Lin28A的表达与乳头甲状腺癌 (PTC) 中的淋巴结转移有关. 这一发现表明,Lin28A可能是晚期PTC病例的治疗点.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
病理学病理学病理学

背景情况:

乳头甲状腺癌 (PTC) 是最常见的内分泌恶性瘤.
在PTC中淋巴结转移是远程转移和死亡的高风险因素.

研究的目的:

调查Lin28A免疫组织化学表达和PTC中的淋巴结转移之间的关联.
在PTC病例中将Lin28A表达与临床病理学数据相关联.

主要方法:

包括143名PTC患者接受了全甲状腺切除和淋巴结解剖.
瘤部分被染色为Lin28A,广泛的细胞质染色被认为是积极的.

主要成果:

在17.5%的PTC病例中观察到Lin28A阳性.
在统计学上发现了Lin28A阳性和淋巴结转移 (P = 0.014),围神经入侵 (P = 0.004) 和甲状腺外扩散 (P = 0.037) 之间存在显著的关联.

结论:

Lin28A的表达与PTC中的淋巴结转移有关.
林28分子通路为耐火或复发性PTC提供了潜在的治疗点.

关键词:

淋巴结转移是淋巴结的转移.皮囊甲状腺癌皮囊甲状腺癌围神经侵袭是一种围神经侵袭.

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lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...