影响HTA-血友病携带者 生命质量评估
Diana Carneiro-Leão1, Rita Queirós-Pereira1, Sofia Teixeira1
1Immunohemotherapy Department, Reference Centre for Congenital Coagulation Disorders, São João Health Local Unit, Porto, Portugal.
概括
与普通人群相比,女性血友病携带者 (HC) 的生活质量更差,出血倾向增加. 早期识别HC对于管理出血风险和改善健康结果至关重要.
科学领域:
- 血液学 血液学 血液学
- 遗传学 是一个遗传学.
- 生活质量研究 研究 生命质量研究
背景情况:
- 早期识别女性血友病携带者 (HC) 对于管理潜在的严重月经出血和确保适当的护理至关重要.
- 积极主动管理有助于HC的孕前,产前,分娩和产后护理.
- 解决血静性挑战需要及时诊断和支持HC.
研究的目的:
- 为了评估女性血友病携带者 (HC) 的出血表型.
- 评估HC女性的与健康有关的生活质量 (HRQOL).
- 为了比较HC和健康对照组之间的出血倾向和HRQOL.
主要方法:
- 在单个中心进行了一项横截面,非干预性研究.
- 国际血栓和血液静止-出血评估工具协会 (ISTH-BAT) 评估了出血表型.
- 简单-36 (SF-36) 问卷评估了HRQOL,以及凝血因子活性和F8/F9基因变异分析.
主要成果:
- HC的ISTH-BAT得分明显高于对照组 (表明更多的出血) (p < 0.001).
- 与对照组相比,HC报告了较低的身体 (p = 0.01) 和精神 (p < 0.001) SF-36分数.
- 患有严重出血表型的HC在所有SF-36领域都有较低的凝血因子水平和较差的HRQOL.
结论:
- 女性血友病携带者 (HC) 与一般女性人口相比,与健康相关的生活质量 (HRQOL) 更差.
- 在HC中,HRQOL与因子VIII/IX水平没有直接相关.
- 在HC中严重出血的表型与显著较低的凝血因子水平有关.
相关概念视频
Assessment of the Cardiovascular System I: Subjective Data
472
A thorough health history and physical assessment are essential for identifying cardiovascular disease (CVD) symptoms and distinguishing them from other health issues.
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
472
Disorders of Hemostasis
1.2K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
1.2K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
180
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
180
Factors Affecting Illness
4.5K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
For instance, risk factors are connected to illness,...
4.5K
Genome-wide Association Studies-GWAS
14.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
14.4K
Healthcare Associated Infections II: Preventive Measures
2.8K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.8K


