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Updated: Sep 16, 2025

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特定于KRAS编码子的突变差异性地切换PI3K通路信号,并改变对inavolisib (GDC-0077) 的敏感性

Kyung W Song1, Christy C Ong2, Eva Lin3

  • 1Genentech Inc, South San Francisco, CA, United States.

Molecular cancer therapeutics
|July 8, 2025
PubMed
概括

结直肠癌中的特定KRAS突变会影响PI3K抑制剂的敏感性. 将inavolisib与MAPK抑制剂结合,在KRAS突变模型中显示出协同效应.

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