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表面工程纳米探测器用于多模式生物成像:从分子设计到光学集成

Leiming Chu¹, Xiaotong Zhang¹, Xurui Cao¹

¹Joint Research Center for Food Derived Functional Factors and Synthetic Biology of IHM, Anhui Provincial International Science and Technology Cooperation Base for Major Metabolic Diseases and Nutritional Interventions, China Light Industry Key Laboratory of Meat Microbial Control and Utilization, School of Food and Biological Engineering, Engineering Research Center of Bio-process, Ministry of Education, Hefei University of Technology, Hefei 230601, P. R. China. zhangyu@hfut.edu.cn.

Chemical communications (Cambridge, England)

|July 8, 2025

概括

表面工程纳米探针克服了传统生物成像剂的局限性,为疾病诊断和治疗提供了增强的可视化. 本综述详细介绍了它们的设计,应用以及未来临床翻译潜力.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
生物成像是一种生物成像.
热浪学是什么意思热浪学

背景情况:

传统的生物成像剂有光白,组织透性差,分布不特异,限制了深层组织和复杂病理的可视化.
这些局限性阻碍了对细胞动态,疾病机制和治疗反应的实时监测.

研究的目的:

系统地审查表面工程纳米探测器的分子设计原则.
探索这些先进的纳米探测器在生物成像和神经科学中的生物医学应用.
概述纳米异能平台临床转化方面的未来前景和挑战.

主要方法:

探索主要的表面工程策略:联体介导准,环境响应,电荷工程,表面涂层和核心外结构.
分析高分辨率,动态,实时和多模式成像中的应用.

主要成果:

表面工程显著提高了纳米探针的性能,解决了传统剂的局限性.
展示的应用涵盖了各种生物成像模式和神经应用.
确定了改善成像深度,分辨率和特异性的关键策略.

结论:

表面工程纳米探测器代表了生物成像和theranostics的重大进步.
进一步开发对于克服临床翻译方面的挑战和提高功能复杂性至关重要.
这些纳米探测器为下一代纳米激光平台提供了基本指导.

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