人类个体是否因其对脂友污染物的生物放大潜力而有所不同?
Yuhao Chen1,2, Terrence H Bell1, Ying Duan Lei1
1Department of Physical and Environmental Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, Ontario, M1C 1A4, Canada. frank.wania@utoronto.ca.
Environmental science. Processes & impacts
|July 8, 2025
概括
生物放大,即生物体中污染物的积累,在人类中显示出显著的个体差异. 消化效率与年龄相关的变化会影响污染物水平,影响人类生物监测结果.
科学领域:
- 环境化学环境化学
- 人类毒理学 人类毒理学
- 生物监测 生物监测
背景情况:
- 生物放大,即越来越多的有机污染物在食物链上升的度,对于理解人类暴露至关重要.
- 量化人类生物放大潜力的个体间差异的研究很少.
- 多双 (PCB) 是人类暴露研究中令人担忧的持久性有机污染物.
研究的目的:
- 在人类中量化生物放大 (BMFlim) 的热力学极限和基于便的生物放大因子 (BMFf).
- 研究生物放大潜力的个体间差异.
- 探索人类消化效率和生物放大之间的关系.
主要方法:
- 应用均衡取样和对配对的食和便样本进行化学分析.
- 测量PCB的生物放大极限 (BMFlim) 和基于便的生物放大因子 (BMFf).
- 评估了血液和便中的脂质同化效率和污染物流动性.
主要成果:
- 与四名年轻参与者相比,一个年长的参与者表现出更高的BMFlim和BMFf值 (分别增加了5倍和7倍).
- 生物放大差异与脂质同化效率的变化有关,范围为93%至99%.
- 血液和便之间的污染物流动性关系有所不同,这表明年轻个体的"脂肪冲洗"效应和老年参与者的近平衡.
结论:
- 消化效率的个体差异显著影响人类的生物放大潜力.
- 年龄可能是影响脂质同化和随后污染物积累的因素.
- 生物放大中的变化有助于观察到人群中污染物水平的差异.
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