标本性肥胖和心血管疾病之间的关联:系统性炎症指数的作用
Yuhong Luo1,2, Chen Xin1,2, Yuhua Liu1,2
1Xuanwu Hospital, Capital Medical University, Beijing, China.
Frontiers in medicine
|July 8, 2025
概括
肥胖症 (SO) 与更高的心血管疾病风险有关. 像AISI和SIRI这样的生物标志物可以帮助管理SO患者并改善心脏健康.
科学领域:
- 心脏病学 心脏病学
- 老年学是一门学科.
- 代谢疾病 代谢疾病
背景情况:
- 有限的研究存在于sarcopenic肥胖 (SO) 和心血管疾病.
- 系统性炎症综合指数 (AISI) 和系统性炎症反应指数 (SIRI) 在SO中的作用未得到充分研究.
研究的目的:
- 调查老年人中sarcopenic肥胖和心血管多病症之间的关联.
- 分析AISI和SIRI对这些协会的缓和作用.
主要方法:
- 对1010名年龄≥50岁的参与者进行了回顾性观察性研究.
- 由低肌肉质量与体重比和高内脏脂肪面积来定义的SO.
- 用于评估关联和适度的多变量分析和约翰逊-尼曼方法.
主要成果:
- 肥胖症与内皮功能障碍,动脉硬性,心脏膜疾病和动脉动脉样硬化显著相关.
- 对AISI (133.48) 和SIRI (0.58) 确定了重要的关联的特定关键点.
结论:
- 肥胖症是心血管疾病的独立风险因素.
- 可以使用AISI和SIRI作为SO患者风险分层的生物标志物.
- 有针对性的管理对于改善SO患者心血管结果至关重要.
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