在非酒精性脂肪性肝病患者中胆结石的发生频率
Uzma Soomro1, Ghulam Abbas2, Muhammad Aslam3
1General Surgery, Sindh Institute of Medical Sciences, Karachi, PAK.
Cureus
|July 8, 2025
概括
非酒精性脂肪肝 (NAFLD) 影响了超过22%的胆结石患者,特别是女性和老年人. 在NAFLD患者中早期查胆结石可以改善结果.
科学领域:
- 肝病学和胃肠道学
- 代谢障碍 代谢障碍 代谢障碍
- 胆道疾病 胆道疾病
背景情况:
- 由于肥胖和糖尿病,非酒精性脂肪性肝病 (NAFLD) 的患病率在全球范围内正在上升.
- 胆结石病与NAFLD具有共同的风险因素,包括肥胖和胰岛素抵抗.
- 关于巴基斯坦NAFLD患者胆结石同时发生的数据有限.
研究的目的:
- 为了确定NAFLD患者胆结石的频率.
- 为了比较NAFLD患者的临床,生化和代谢资料,有和没有胆结石.
主要方法:
- 在喀拉的辛德泌尿病与移植研究所进行的一项横截面观测研究.
- 通过超声波诊断的246名成年NAFLD患者被纳入; 排除适用于酒精使用,其他肝脏疾病和改变脂质的药物.
- 禁食腹部超声波用于NAFLD和胆结石诊断;数据使用SPSS v26.0.0.进行分析.
主要成果:
- 在246名NAFLD患者中,有55人 (22.4%) 诊断出胆结石.
- 在女性 (62%) 中,患病率更高,平均年龄为48.3±10.2岁.
- 与胆结石有意义的关联包括晚年 (p=0.013),女性性别 (p=0.037),高马-氨基转酶 (GGT) (p=0.029) 和高甘油三血症 (p≤0.01).
结论:
- 在NAFLD患者中观察到胆结石病的显著同时发生率为22.4%.
- 确定的主要危险因素是女性性别,年龄较大,高甘油三血和高GGT.
- 建议在NAFLD患者中及时进行胆结石查,以预防胆道并发症和改善结果;建议进行多中心前性研究.
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