严重酒精性肝炎患者的小肠细菌过度生长:频率和预测因素
Venkatesh Vaithiyam1, Sanjeev Sachdeva1, Payila Aneesh1
1Gastroenterology, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, New Delhi, IND.
Cureus
|July 8, 2025
概括
小肠细菌过度生长 (SIBO) 在严重酒精性肝炎 (SAH) 患者中更为常见. 占主导地位的甲生产商更有可能患有SIBO.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 小肠细菌过度生长 (SIBO) 是一种与异常肠道微生物群相关的肠道疾病.
- 严重的酒精性肝炎 (SAH) 是一种严重的肝病,具有潜在的肠道并发症.
研究的目的:
- 为了确定SAH患者SIBO的频率.
- 为了确定SAH患者中SIBO的预测因子.
主要方法:
- 葡萄糖呼吸试验 (GHBT) 用于诊断SIBO.
- 包括60名SAH患者和30名健康对照 (HC).
- SIBO被定义为呼吸中或甲的增加>12 ppm.
主要成果:
- 在25%的SAH患者中,SIBO被诊断为SAH,而在HC患者中为3.3% (p=0.017).
- 在单变量分析中,占主导地位的甲生产者地位是一个重要的预测因素.
- 在多变量分析中,占主导地位的甲生产者地位使SIBO风险增加了17.44倍 (aOR 17.44,p=0.001).
结论:
- 与健康个体相比,SAH患者中SIBO的患病率明显高.
- 占主导地位的甲生产者地位是SAH中SIBO的独立预测因素.
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