人的肠道微生物群与宿主生活方式有关:一个全面的叙事审查
Qin Zeng1,2, Xianqiong Feng3,4, Yanling Hu1,2
1Department of Pediatrics Nursing, West China Second University Hospital, Sichuan University, Chengdu, China.
Frontiers in microbiology
|July 8, 2025
概括
饮食,睡眠和运动等生活方式因素显著影响肠道微生物群. 了解它们的综合作用是开发针对代谢和免疫健康的微生物群干预措施的关键.
科学领域:
- 微生物组研究的研究.
- 主体-微生物相互作用
- 生活方式医学生活方式医学
背景情况:
- 肠道微生物群是生活方式和宿主生理学之间的关键调解者.
- 缺乏对肠道微生物群 (肠道微生物群) 的生活方式因素 (饮食,睡眠,运动) 的综合理解.
- 这种差距阻碍了针对代谢和免疫疾病的基于微生物的向干预.
研究的目的:
- 综合评估生活方式干预措施对肠道微生物群落的协同效应.
- 识别当前研究中的知识差距和方法挑战.
- 为个性化微生物群调节提出框架和策略.
主要方法:
- 系统的文献综述 (2000年至今) 的PubMed,科学网络,Scopus.
- 专注于微生物组分析,控制的生活方式干预和多omics数据的研究.
- 从临床和临床前研究中优先考虑的机制性见解,评估方法.
主要成果:
- 富含纤维的饮食增加有益细菌 (例如,SCFA生产者),具有个体间的变化.
- 循环节律的破坏减少了微生物的多样性,增加了炎症.
- 运动员表现出独特的微生物特征,具有增强的代谢潜力.
结论:
- 综合证据成为生活方式与微生物群相互作用的框架.
- 在研究设计和数据解释方面发现了挑战.
- 建议标准化方法和转化策略,用于个性化微生物群调制,以改善健康结果.
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