在蜜蜂模型中,Phocaeicola coprocola在调节学习和记忆行为方面具有益生菌潜力
Mengqi Xu1,2, Xiaohan Zhang1,3, Xi Luo4
1Microbiota Laboratory, Clinical Division of Microbiota, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Frontiers in microbiology
|July 8, 2025
概括
福西科拉 (Phocaeicola coprocola) 补充剂增强了蜜蜂的认知功能和肠道多样性. 这表明它作为益生菌对大脑健康的潜力,通过肠道微生物和代谢变化进行介导.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 代谢学 代谢学 代谢学
背景情况:
- 肠道微生物失调与大脑疾病有关.
- 在与大脑相关的疾病中观察到Focaeicola coprocola枯竭.
- 目前尚不清楚P. coprocola的神经保护作用.
研究的目的:
- 为了研究P. coprocola对认知表现的影响.
- 探索P.coprocola对微生物群-肠-大脑轴的影响的潜在机制.
- 利用蜜蜂模型进行临床前益生菌查.
主要方法:
- 蜜蜂被分为对照组和补充P. coprocola的组.
- 通过嗅觉学习和记忆测试来评估认知表现.
- 用16S rRNA测序和LC-MS/MS分析了肠道微生物群和代谢资料.
主要成果:
- P. coprocola显著提高了学习成功率 (74.13%与50.85%相比).
- 肠道微生物多样性 (香农指数) 和肠道脂质代谢得到增强.
- 增加的保护性脂质与特定的肠道细菌相关.
结论:
- 科普罗科拉 (P. coprocola) 是一种有前途的益生菌,可以增强认知能力.
- 肠道微生物和代谢相互作用是P. coprocola作用的关键.
- 蜜蜂是微生物群-肠-大脑轴研究的宝贵模型.
相关概念视频
01:19Role of Hippocampus in Memory
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
01:22Probiotics
Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...