非编码RNAs作为肝炎B病毒相关的肝细胞癌的关键调节剂
Prasanna Srinivasan Ramalingam1, Liming Zhang2, Md Sadique Hussain3,4
1Protein Engineering Lab, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India.
Frontiers in immunology
|July 8, 2025
概括
非编码RNAs (ncRNAs) 是乙型肝炎病毒 (HBV) 诱导的肝癌 (HCC) 发展的关键参与者. 这些分子作为诊断生物标志物和HBV相关HCC的治疗点具有前途.
科学领域:
- 分子生物学分子生物学
- 在瘤学瘤学.
- 肝病学 肝病学是一种肝病学.
背景情况:
- 与乙型肝炎病毒 (HBV) 感染相关的肝细胞癌 (HCC) 是一个主要的全球健康问题,治疗选择有限.
- 非编码RNAs (ncRNAs) 越来越多地被认为是它们在癌症发展中的调节作用,包括HBV诱导的瘤发生.
研究的目的:
- 审查涉及HBV相关HCC的ncRNAs的不同类型和调控机制.
- 突出ncRNAs作为HBV-HCC的诊断生物标记物和治疗点的潜力.
- 讨论基于ncRNA的新兴策略,以改善HBV-HCC患者的治疗结果.
主要方法:
- 在HBV相关的HCC背景下调查ncRNA的研究的综合文献综述.
- 分析各种ncRNA类 (microRNAs,长ncRNAs,圆形RNAs,小核RNAs) 在癌症特征中的作用.
- 基于ncRNAs在生物流体中的稳定性和检测能力的诊断和预后潜力的评估.
主要成果:
- ncRNAs通过调节关键癌症特征并促进HCC进展,显著影响HBV诱导的瘤发生.
- ncRNAs具有双重作用,在与HBV相关的HCC中充当瘤基因和瘤抑制剂.
- 体液中ncRNAs的稳定性和特异性表达模式使它们成为早期检测和诊断HBV-HCC的有希望的生物标志物.
结论:
- ncRNAs是HBV相关HCC的发病过程中的关键调节者.
- ncRNAs作为HBV-HCC的非侵入性诊断标记物和新型治疗点具有显著的潜力.
- 对基于ncRNA的方法的进一步研究对于推进这种恶性瘤的治疗和管理至关重要.
相关概念视频
02:39lncRNA - Long Non-coding RNAs
9.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.0K
01:29Viruses with RNA Genomes
137
RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
137
01:58Cell Specific Gene Expression
14.0K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
14.0K
01:23Types of RNA
65.3K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
65.3K
01:51Mechanisms of Retrovirus-induced Cancers
5.3K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
5.3K
02:30siRNA - Small Interfering RNAs
17.0K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
17.0K