通过肠道菌群微生物对中风后神经炎症反应的调节
Wanying Xie1, Xue Yan2, Xu Yang2
1College of Integrated Traditional Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun, China.
Frontiers in cellular and infection microbiology
|July 8, 2025
概括
肠道微生物群通过微生物群-肠道-大脑轴 (MGBA) 影响缺血性中风 (IS). 调节肠道微生物群为减少神经炎症和改善IS患者的治疗结果提供了潜在的治疗策略.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 缺血性中风 (IS) 是导致残疾和死亡的主要原因.
- 微生物群-肠-大脑轴 (MGBA) 越来越多地被认为在中枢神经系统疾病中的作用.
- 神经炎症对IS的发病和结果有着显著的贡献.
研究的目的:
- 审查微生物群-肠-大脑轴 (MGBA) 在缺血性中风 (IS) 中的作用.
- 要总结IS后的免疫反应.
- 讨论针对IS的MGBA的当前和潜在的治疗策略.
主要方法:
- 对临床前和临床证据的审查.
- 对便微生物种移植 (FMT),益生菌,益生菌,饮食和抗生素的研究进行分析.
- 综合有关神经炎症,血脑屏障完整性和免疫调节的数据.
主要成果:
- MGBA通过神经,免疫和代谢途径影响IS.
- 像FMT和益生菌这样的干预措施在抑制神经炎症方面表现有前途.
- 调节肠道微生物群可以保护血脑屏障,改善中风的结果.
结论:
- MGBA是IS发展和进步的一个关键因素.
- 准MGBA为IS提供了新的治疗途径.
- 对基于MGBA的治疗方法的进一步研究可能会导致改善IS管理.
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