在个性化医疗保健中,营养基因组学和低碳水化合物食之间的相互作用
Yousef M Almoghrabi1,2, Basmah M Eldakhakhny1,3, Abdulhadi I Bima1,3
1Clinical Biochemistry Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Frontiers in nutrition
|July 8, 2025
概括
营养基因组学和营养遗传学通过研究基因-营养物相互作用来个性化饮食. 了解基因对低碳水化合物饮食 (LCKD) 的影响,是定制健康策略和疾病预防的关键.
科学领域:
- 营养基因组学和个性化医学.
背景情况:
- 营养学研究了饮食对基因表达的影响,营养素作为信号分子.
- 营养遗传学研究遗传变异如何影响营养代谢和健康结果.
- 个性化营养旨在通过根据个体遗传特征定制饮食来改善健康和预防疾病.
研究的目的:
- 审查营养基因组学的重要性,重点关注低碳水化合物类饮食 (LCKD) 与遗传因素之间的相互作用.
- 强调了解这些相互作用对于制定个性化的饮食策略的重要性.
- 在精确的健康框架内,为个性化的营养指导做出贡献.
主要方法:
- 关于营养基因组学,营养基因学和LCKD的文献综述.
- 分析营养素如何影响细胞过程,基因表达和表观遗传修饰.
- 检查影响营养代谢和对饮食干预措施的反应的遗传变异.
主要成果:
- 这种LCKD会影响基因表达和表观遗传机制,影响炎症,氧化应激和代谢调节.
- 慢性肺结核病与改善胰岛素敏感性,血糖控制,脂质概况和体重减轻有关.
- 遗传因素显著影响个人对LCKD的反应,需要进一步调查.
结论:
- 对营养基因组学和LCKD相互作用的全面理解对于优化饮食益处至关重要.
- 个性化的饮食策略可以减轻LCKD风险并增强其积极影响.
- 将遗传洞察力纳入饮食规划,支持精确的健康和个性化的营养指导.
相关概念视频
Chronic Kidney Disease III: Interprofessional Care
82
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
82
Carbohydrate Metabolism
11.8K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.8K
Combination Therapies and Personalized Medicine
5.1K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K
Overview of Carbohydrate Metabolism
1.9K
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
1.9K
Regulation of Metabolism
9.9K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
9.9K
Issues And Trends In Healthcare Delivery System
5.9K
The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
5.9K


