韦兹曼尼亚凝血菌BC99通过恢复肝脏-脏-肠轴功能障碍而缓解高尿血症,这是由高尿血症引起的
Ying Wu1,2, Yinyin Gao1, Cheng Li1
1College of Food and Bioengineering, Henan University of Science and Technology, Luoyang, P.R. China. shaobingu@haust.edu.cn.
Food & function
|July 8, 2025
概括
威兹曼尼亚凝血菌BC99通过改变脏和肠道的再吸收和分泌来降低尿酸. 这种益生菌还可以改善肠道微生物群和新陈代谢,为管理高尿素血症 (HUA) 提供了一个有前途的方法.
科学领域:
- 微生物学 微生物学
- 代谢障碍 代谢障碍 代谢障碍
- 胃肠病学 胃肠病学
背景情况:
- 超尿血症 (HUA) 是一种具有重大健康影响的全球代谢障碍.
- 了解HUA的新型治疗策略至关重要.
研究的目的:
- 为了研究Weizmannia coagulans BC99.9的抗高尿素作用和机制.
- 评估BC99对尿酸代谢和肠道微生物群的影响.
主要方法:
- 建立超尿血症小鼠模型.
- 对尿酸再吸收和分泌蛋白质在脏和肠道中的分析.
- 对Nrf2/NLRP3通路的研究.
- 肠道微生物群的组成和代谢物分析 (SCFA,氨基酸, purin,pyrimidine).
主要成果:
- BC99显著降低了UA再吸收的调节,并提高了UA分泌蛋白的调节.
- 通过Nrf2/NLRP3通路进行BC99调节的UA合成.
- BC99恢复了肠道微生物群的失调,增加了SCFA产生细菌,并纠正了代谢障碍.
结论:
- 威兹曼尼亚凝血素BC99显示出强大的抗高尿素效应.
- BC99通过调节和肠道UA运输以及Nrf2/NLRP3通路而起作用.
- BC99显示出作为一种饮食补充剂的潜力,用于管理高尿血和改善肠道健康.
相关概念视频
Drugs for Treatment of Ulcerative Colitis in IBD
242
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
242
Gastritis III: Clinical Manifestations and Management
493
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
493
Gastritis-II: Pathophysiology
579
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
579
Nephrotic Syndrome II : Assessment and Medical Management
24
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
24
Acid Suppressive Drugs for Peptic Ulcer Disease: Histamine H2-Receptor Antagonists
573
Histamine H2 receptors, which are intricately located on the basolateral membrane of parietal cells, play a crucial role in modulating gastric acid secretion. When released from enterochromaffin-like cells, histamine engages H2 receptors, initiating the cyclic AMP (cAMP) pathway. In this pathway, adenylyl cyclase converts ATP into cAMP, elevating intracellular cAMP levels. The activation of protein kinase A follows, stimulating the proton pump. This stimulation prompts the secretion of hydrogen...
573
Nephrotic Syndrome I : Introduction
31
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
31


