在人类带血中鉴定菌体DNA
Jennifer A Sequoia1, Naomi L Haddock2, Paw Mar Gay1
1Division of Neonatal and Developmental Medicine, Department of Pediatrics.
JCI insight
|July 8, 2025
概括
在人类的带血液中检测到了菌体DNA,这表明胎儿在怀孕期间暴露. 这一发现表明,从母亲到胎儿的细菌的垂直传播是可能的.
科学领域:
- 微生物学 微生物学
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 菌体 (菌体),病毒感染细菌,在人类微生物群中普遍存在.
- 菌体可能通过与细菌宿主的相互作用影响人类健康.
- 内源性菌体或其产品在怀孕期间从母亲向胎儿的垂直传播仍未得到研究.
研究的目的:
- 为了调查母体和带血中菌体DNA的存在.
- 为了确定细菌是否从母亲垂直传播到胎儿.
主要方法:
- 在无细胞DNA (cfDNA) 中从五个数据库中搜索细菌序列 (共474,031个序列).
- 分析了来自两个独立队伍 (10对和62对) 的双对母体和带血样本.
- 包括患有妊娠前症,早产或膜炎的孕妇的样本.
主要成果:
- 从第一和第二个队伍的母体和带血中分别识别了94和596个菌体序列cfDNA.
- 检测到58个菌素序列跨母婴二和581个独特的菌素序列.
- 没有发现菌素序列与妊娠前,早产或胆膜炎之间存在一致的关联.
结论:
- 证明了在出生时人类带血中存在菌体DNA.
- 提供了人类胎儿在子宫内暴露于菌体DNA的证据.
- 表明细菌体或它们的遗传物质的潜在垂直传播.
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