通过信号通路改善高血压的植物性天然产品:一篇评论
Yushen Feng1,2,3, Juan Zhou1, Min Zhong1
1Anhui Province Key Laboratory of Non-Coding RNA Basic and Clinical Transformation (Wannan Medical College), Central Laboratory, Yijishan Hospital of Wannan Medical College, Wuhu, China.
The American journal of Chinese medicine
|July 8, 2025
概括
天然产品在治疗高血压方面表现有前途,高血压是一种广泛的疾病,影响超过10亿人. 研究强调了黄类,类和类作为潜在的抗高血压剂,向关键疾病途径.
科学领域:
- 药理学和天然产品化学
- 心血管疾病研究研究
- 综合医学是一个整体的医学.
背景情况:
- 高血压影响全球超过10亿人,增加心血管疾病的风险.
- 基本动脉高血压是中风,衰竭,心脏缩和心脏衰竭的主要危险因素.
- 现有的抗高血压药物对许多患者来说不足,需要新的治疗策略.
研究的目的:
- 审查2019年至2024年期间发表的具有潜在抗高血压作用的天然产品 (NP).
- 识别和分类针对关键高血压发病路径的NP.
- 评估NP作为新型抗高血压药物的来源的潜力.
主要方法:
- 在PubMed和Web of Science数据库中的系统文献搜索.
- 包括2019年至2024年出版的具有抗高血压潜力的NP研究.
- 根据结构框架 (黄类,类,类,植物提取物) 确定NP的分类.
主要成果:
- 确定了70种具有潜在抗高血压活性的独特天然产品.
- 这些NP被分为黄类 (20),类 (24),类 (17) 和植物提取物 (9).
- 这些化合物向包括氧化应激,炎症,血管重塑和神经激素信号传递在内的途径.
结论:
- 自然产品为开发新的抗高血压疗法提供了一个有希望的途径.
- 未来的研究应该专注于具有双重抗氧化/抗炎特性和改进的输送系统的NP.
- 包括合成生物学在内的跨学科方法对于可扩展的NP生产至关重要.
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