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Updated: Sep 16, 2025

Synthesis of Wavelength-shifting DNA Hybridization Probes by Using Photostable Cyanine Dyes
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可调节的化DNA探针驱动快速和高分辨率的单分子光成像

Mirjam Kümmerlin1,2, Qing Zhao1,2, Jagadish Hazra1,2

  • 1Department of Physics, University of Oxford, Oxford OX1 3PU, United Kingdom.

Nucleic acids research
|July 8, 2025
PubMed
概括

研究人员开发了新的化DNA探针,以克服单分子光 (SMF) 测量中的高度障碍. 这些探测器能够显著提高度,增强超高分辨率成像和分子跟踪能力.

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Labeling DNA Probes03:31

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
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