在血液溶解的血清,血和全血样本中测量的正确度
John Toffaletti1, Alan H B Wu2
1Department of Pathology, Duke University Medical Center, Durham, NC, United States.
The journal of applied laboratory medicine
|July 8, 2025
概括
样本血液溶解是影响结果的常见问题,特别是在重症监护中. 使用血红蛋白分析纠正血液溶解可能导致不准确的水平,建议使用替代报告方法.
科学领域:
- 临床化学 临床化学
- 预分析变量 预分析变量
背景情况:
- 样本血液溶解是临床实验室中一个重要的预分析问题.
- 血液溶解的高率发生在紧急和重症监护病房的样本中.
- 血液溶解严重影响的解释,这是一个临床上重要的分析剂.
研究的目的:
- 审查使用自由血红蛋白水平纠正血清/血度的方法.
- 评估当前用于纠正受血解影响的结果的方法的适当性.
主要方法:
- 关于的血液溶解校正的已发表报告的文献综述.
- 基于自由血红蛋白测量结果,分析开发的用于估计结果的方程.
- 考虑全血检测可用的血液溶解检测方法.
主要成果:
- 基于血红蛋白分析的校正方程可能会产生不准确的结果.
- 对于的这些校正方程的临床适当性是可疑的.
- 定性评论或报告一系列经校正的值可能更合适.
结论:
- 使用血红蛋白分析纠正血液溶解并不总是准确或适合.
- 应考虑替代报告策略,如定性评论或结果范围,用于血液化样本.
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