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Updated: Sep 16, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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对CDK12/13和BRD4分子降解器的合理设计

Zhe Zhuang1, Woong Sub Byun1, Zuzanna Kozicka2,3

  • 1Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, CA, 94305, USA.

Angewandte Chemie (International ed. in English)
|July 8, 2025
PubMed
概括

本研究提出了一个合理的设计策略,用于创建分子降解剂,一种新的治疗类. 通过添加特定的化学组,研究人员可以将现有的抑制剂转化为强大的蛋白质降解剂,用于疾病治疗.

关键词:
含有odomain 的蛋白质4循环素依赖性激酶12/13 的作用.分子粘合剂是一种分子粘合剂.有针对性的蛋白质降解降解.

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