三种棕树种 (Arecaceae家族) 的多性特征,肝保护性评估和分子对接研究
Fadila M Hamed1, Heba E Elsayed2, Mohamed S Mady3
1Department of Pharmacognosy, Faculty of Pharmacy, October 6 University, Giza, 12585, Egypt.
概括
三种Arecaceae物种的叶子提取物显示出对药物诱导的肝损伤有显著的肝保护作用. 这些植物提取物表现出抗氧化,抗炎和抗性质,这归因于它们丰富的和黄含量,这表明它们具有治疗潜力.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
背景情况:
- 传统上,Arecaceae家族的植物用于治疗炎症和肝脏疾病.
- 需要对肝脏保护潜力的科学验证和在特定的Arecaceae物种中识别活性化合物.
研究的目的:
- 为了识别Aiphanes eggersii,Carpoxylon macrospermum和Jubaeopsis caffra叶的水性甲醇提取物 (AME) 中的成分.
- 在药物诱导的肝损伤模型中评估这些AME的肝保护潜力.
- 研究AMEs的抗氧化,抗炎和抗的作用.
主要方法:
- 在药物诱导的肝损伤小鼠模型中,从A. eggersii,C. macrospermum和J. caffra叶片中制备和施用水性甲醇提取物 (AME).
- 肝酶,氧化应激标志物 (MDA,GSH,SOD),炎症标志物 (NF-κB,TNF-α,IL-1β) 和亡标志物 (BAX,Bcl2,caspase-3) 的评估.
- 使用HPLC-MS/MS进行植物化学分析,以识别和定量化合物.
- 关键化合物 (rutin,hesperidin) 与标蛋白 (SOD-1,caspase-3) 的分子对接研究和分子动力学模拟.
主要成果:
- 另外的一种药物在5g/kg的剂量内是安全的,并且在500和1000mg/kg剂量时表现出显著的肝保护作用.
- 肝酶,MDA,NF-κB,TNF-α,IL-1β,BAX和caspase-3的显著减少,GSH和SOD水平增加.
- 在HPLC-MS/MS检测中,发现了高含量,主要化合物是酸,香草酸,素,超酸和素.
- 分子对接表明,鲁丁和hesperidin对SOD-1和caspase-3具有强烈的结合亲和力.
结论:
- 研究的Arecaceae物种 (A. eggersii,C. macrospermum,J. caffra) 具有显著的肝保护活性.
- 观察到的有效性归因于丰富的和黄成分,表现出抗氧化,抗炎和抗性质.
- 需要进一步的临床研究来探索这些植物提取物的治疗潜力.
关键词:
艾法尼斯 (Aiphanes eggersii) 是一个虫.卡波西隆宏观精子 (Carpoxylon macrospermum) 是一种精子.朱贝奥普西斯 (Jubeaopsis caffra) 是一个植物.在HPLCMS/MS/MS中使用.肝脏保护性 肝脏保护性分子对接是分子对接.更多相关视频
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