鉴定血清尿酸值,增加1型糖尿病中糖尿病病的风险
Mei Huang1, Qianying Wei1, Xin Chen1
1Department of Endocrinology, the First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing, China.
概括
较低的血清尿酸 (SUA) 水平在1型糖尿病 (T1DM) 中很常见,并表明糖尿病病 (DN) 的风险增加,确定了4.30 mg/dL的值.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 1型糖尿病 (T1DM) 是一种慢性疾病,需要持续治疗以预防并发症.
- 糖尿病病 (DN) 是糖尿病的一个显著的微血管并发症,导致损伤.
- 血清尿酸 (SUA) 水平已被探索为各种代谢和脏疾病的潜在生物标志物.
研究的目的:
- 研究1型糖尿病 (T1DM) 的中国患者血清尿酸 (SUA) 水平与糖尿病病 (DN) 风险之间的相关性.
- 确定与患糖尿病病 (DN) 风险增加相关的最佳血清尿酸 (SUA) 值.
主要方法:
- 一项涉及913名T1DM患者的病例控制研究与年龄和性别的健康对照进行了匹配.
- 多变量后勤回归和受限立方线 (RCS) 分析,以评估SUA和DN风险之间的关联,并确定最佳的SUA值.
- 使用斯皮尔曼相关性和线性混合效应模型进行纵向分析,以评估SUA变异性与估计的膜过率 (eGFR) 和尿蛋白肌素比率 (UACR) 随时间变化的相关性.
主要成果:
- 与对照组相比,T1DM患者的中位数SUA水平 (4.24 mg/dL) 显著降低 (4.93 mg/dL).
- 较低的SUA水平与DN风险相反相关;特别是,SUA的四分位数4显示风险增加了3.01倍 (OR:3.01;1.44-6.50).
- 确定了4.30 mg/dL的最佳SUA值,超过该值,DN风险增加. SUA的变化与eGFR和UACR的变化相关,随着时间的推移,SUA和eGFR之间发现了负相关性,而SUA和UACR之间存在正相关性.
结论:
- 血清尿酸 (SUA) 水平降低在1型糖尿病 (T1DM) 患者中很普遍.
- 血清尿酸 (SUA) 值为4.30 mg/dL被确定为糖尿病病 (DN) 风险增加的重要指标.
- 这些发现表明,SUA可能作为监测T1DM患者DN风险的潜在生物标志物.
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