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在试验感染HPAI clade 2.3.4.4b H5N1病毒后,小鹿的传播和病原性

Luca Bordes¹, Nora M Gerhards¹, Marit Roose¹

¹Wageningen Bioveterinary Research, Lelystad, Netherlands.

The Journal of general virology

|July 8, 2025

概括

高致病性禽流感H5N1类2.3.4.4b病毒正在欧洲越来越多地感染野生哺乳动物. 这项研究表明,这些病毒可以在哺乳动物之间传播,增加了动物感染潜力和监测的需要.

科学领域:

兽医病毒学兽医病毒学
动物传播疾病动物传播疾病
野生动物流行病学

背景情况:

高致病性禽流感 (HPAI) H5N1 clade 2.3.4.4b 野生哺乳动物病毒爆发在欧洲有所增加.
神经学症状和大脑中的高病毒载荷表明哺乳动物中存在严重的HPAI H5N1疾病,尽管可能会发生亚临床感染.
哺乳动物HPAI H5N1感染由于人类传播的可能性而构成动物性感染风险.

研究的目的:

为了调查HPAI H5N1分类2.3.4.4b病毒在中的致病性和传染性,人类流感的一个模型.
为了比较来自家禽的HPAI H5N1病毒和来自红狐的两种病毒的影响,其中包括一种具有动物性突变的病毒 (PB2-E627K).

主要方法:

用三种不同的HPAI H5N1 clade 2.3.4.4b病毒对子进行实验感染.
评估病毒分泌,发病率,死亡率和神经症状.
使用具有PB2-E627K突变的病毒对哺乳动物传播的调查.

主要成果:

红狐衍生的HPAI H5N1病毒导致比家禽衍生的病毒更高的发病率,死亡率和病毒分泌率.
具有PB2-E627K突变的HPAI H5N1病毒在之间传播,导致接受动物的神经症状和病毒抗原存在.
体表现出不同的致病性和病理性,取决于病毒分离.

结论:

在哺乳动物中,HPAI H5N1 clade 2.3.4.4b 病毒表现出可变的致病性.
哺乳动物对哺乳动物传播HPAI H5N1是可能的,特别是携带特定突变的病毒,如PB2-E627K.
加强对野生哺乳动物的监测对于检测具有动物感染潜力的HPAI H5N1菌株至关重要.

关键词:

这是一种H5N1流感.PB2-E627K 这是一本书.禽流感是禽流感的一种疾病.子子子传输传输传输传输传输传输

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