住院后精神分裂症和双相情感障碍的差异性认知和临床改善:基于时钟绘图测试的比较分析
Ahmad Pirani1, Atiye Sarabi-Jamab2,3, Faeze Bostan1
1Mental Health Research Center, Psychosocial Health Research Institute, Department of Psychiatry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
PloS one
|July 8, 2025
概括
患有精神分裂症 (SCZ) 和双相情感障碍 (BDP) 的住院患者表现出认知和临床改善. 与BDP患者相比,精神分裂症患者在时钟绘图测试 (CDT) 上的改善较小.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知心理学 认知心理学
背景情况:
- 精神分裂症 (SCZ) 和双相情感障碍与精神病特征 (BDP) 是严重的精神疾病.
- 认知障碍在SCZ和BDP中很常见,但比较研究有限.
- 了解这些疾病中的认知变化对于治疗至关重要.
研究的目的:
- 在住院SCZ和BDP患者中使用时钟绘图测试 (CDT) 来比较认知功能变化.
- 调查认知变化与正/负症状之间的关联.
- 为了评估住院期间的临床改善.
主要方法:
- 一项对84名伊朗患者 (42名SCZ,42名BDP) 的横截面研究.
- 通过CDT评估认知功能;通过阳性和阴性综合征尺度 (PANSS) 和临床全局印象 (CGI) 评估症状.
- 在入院和出院时收集的数据;统计分析包括配对t测试和多重回归.
主要成果:
- 无论SCZ和BDP组都在住院后在临床和认知上有所改善.
- 双极性障碍患者在CDT,积极症状和CGI得分方面表现出更大的改善.
- 精神分裂症患者在负面症状中表现出更大的改善;CDT变化和症状变化之间没有发现相关性.
结论:
- 认知恢复轨迹在SCZ和BDP之间可能有所不同,SCZ患者的CDT改善较小.
- 在SCZ的认知变化似乎独立于积极/消极的症状波动,但与基线认知相关.
- 建议通过全面的神经认知评估进行进一步的研究,以澄清认知轨迹.
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