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Updated: Sep 16, 2025

Assay for Blood-brain Barrier Integrity in Drosophila melanogaster
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在MDM2-p53轴调节诺林/frizzled4信号和血液-中枢神经系统屏障功能

Jacklyn Levey1,2, Md Abedin1, Chi Zhang3

  • 1Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN 55455, USA.

Science signaling
|July 8, 2025
PubMed
概括

这种p53蛋白质通过抑制内皮细胞中的norrin/frizzled4信号传递,损害了血脑屏障的功能. 准MDM2可能会危及这一障碍,而NCAPH是潜在的FEVR基因.

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