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Updated: Sep 16, 2025
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为由EURL ECVAM协调并涉及EU-NETVAL实验室的甲状腺验证研究进行化学品选择
Camilla Bernasconi1, Stavroula Sampani1, Anna Beronius2
1European Commission, Joint Research Centre, Ispra, Italy.
ALTEX
|July 8, 2025
概括
甲状腺验证研究选择了30种化学物质,以验证识别甲状腺激素破坏者的非动物方法. 这项研究利用机械学见解推进了对内分泌干扰物的评估.
科学领域:
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
- 化学安全评估 化学安全评估
背景情况:
- 甲状腺激素的干扰对人类健康构成风险.
- 非动物测试方法对于评估内分泌干扰剂至关重要.
- 现有的方法需要验证可靠性和机理性理解.
研究的目的:
- 验证用于识别甲状腺激素破坏者的非动物方法.
- 评估所选方法的机制相关性.
- 为方法验证建立一个强大的化学套件.
主要方法:
- 一个循序渐进的化学选择过程,使用文献审查和专家判断.
- 为所选方法制定标准操作程序.
- 使用30种验证化学品的多样化组合的方法的机制性评估.
主要成果:
- 为方法验证,建立了一组精选的30种化学品.
- 该研究确保了广泛的化学空间表示和机械覆盖.
- 获得了关于非动物方法机械学相关性的见解.
结论:
- 经过验证的非动物方法将加强对内分泌干扰物的鉴定和评估.
- 这些发现支持监管决策和采用替代测试策略.
- 这项研究有助于对甲状腺激素作用和干扰的多方面的理解.
相关概念视频
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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
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01:23The Thyroid Gland
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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
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