一个匹配的回顾性分析:替代疗法与骨折发生率之间的关系
Simbarashe J Peresuh1, Paul-Hugo Arcand, Joseph Confessore
1From the Department of Orthopaedic Surgery, The Warren Alpert Medical School of Brown University, Providence, RI (Peresuh, P.-H. Arcand, Confessore, Parvaresh-Rizi, Testa, Quinn, M. A. Arcand, and Daniels), and the Division of Urology, The Warren Alpert Medical School of Brown University, Providence, RI (Avellino).
概括
替代疗法 (TRT) 显著降低了患者的部骨折风险. 这项研究发现,TRT使用与关节骨折的可能性降低了1.9倍,突出了潜在的骨健康益处.
科学领域:
- 整形外科 整形外科 整形外科
- 内分泌学 在内分泌学.
- 老年病的医生 老年病的医生
背景情况:
- 替代疗法 (TRT) 与骨折发生率之间的联系尚未得到充分证实.
- 关节骨折是一个重大的公共卫生问题,特别是在老年人群中.
研究的目的:
- 调查TRT与骨骨折发生率之间的关联.
- 为了确定TRT是否影响大患者队列中关节骨折的风险.
主要方法:
- 一项使用PearlDiver Mariner165数据库的回顾性队列研究.
- 匹配了301,724名患者 (TRT组与对照组),随访时间为2年.
- 使用国际疾病分类代码评估关节骨折发生率,并使用多变量逻辑回归分析.
主要成果:
- 接受TRT的患者部骨折发生率较低 (0.13%vs. 0.25%,P<0.001).
- 使用TRT与部骨折风险降低有关 (调整后几率比率[aOR]=0.58,P<0.001).
- 在男性 (aOR = 0.61) 和女性 (aOR = 0.49) 均观察到降低风险.
结论:
- 处方TRT与明显降低关节骨折的可能性有关.
- TRT可能对骨健康有好处,并可能改善骨科干预的结果.
- 需要对TRT和脆弱性骨折进行进一步的研究.
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