在印度东部 (2019-2023) 临床怀疑结核病的人中非结核菌感染 (2019-2023)
Sunil Swick Rout1, Jyotirmayee Turuk1, Narayana Swamy Dm1
1Microbiology Division, ICMR-Regional Medical Research Centre, Chandrasekharpur, Bhubaneswar, Odisha 751023, India.
Journal of infection and public health
|July 8, 2025
概括
在全球范围内,非结核菌 (NTM) 感染正在上升,奥迪沙的疑似病例患病率为8.1%. 鉴定物种和药物敏感性测试对于有效治疗和预防抗菌素耐药性至关重要.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 全球非结核菌 (NTM) 感染的发病率正在增加.
- 由于耐药性,NTM感染带来了诊断和治疗方面的挑战.
- 特定物种的药物敏感性有所不同,需要量身定制的治疗方案.
研究的目的:
- 调查印度奥迪沙州NTM感染的流行病学.
- 确定流行的NTM物种及其药物易感性模式.
- 为了告知有针对性的治疗策略和抗菌药物管理.
主要方法:
- 在828个疑似样本中使用线式探针测定进行培养和物种识别.
- 通过MIC断点确定的抗菌细菌敏感性测试.
- 分析遵循临床和实验室标准研究所 (CLSI) M24-S指南.
主要成果:
- 在8.1% (67/828) 的样本中发现了NTM.
- 最常见的物种:M. 细胞内 (32.8%),M. (22.3%),M. 偶然 (11.9%).
- 在沿海地区和男性 (65.7%) 患病率更高;观察到多种药物敏感性,M. avium和M. abscessus对多种药物表现出耐药性.
结论:
- 精确的物种级别识别和药物敏感性测试对于NTM感染至关重要.
- 向治疗改善了患者的治疗结果,并打击了抗菌素耐药性.
- 奥迪沙州的流行病学数据突出显示了区域趋势和特定物种的流行率.
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