调节社区的氧化还原代谢,以系统地减轻抗生素化学和生物风险
Ke Shi1, Wen-Bin Xu1, Han-Lin Cui2
1State Key Laboratory of Urban-rural Water Resource and Environment, School of Eco-environment, Harbin Institute of Technology, Shenzhen 518055, PR China.
Water research
|July 8, 2025
概括
微空气和电刺激增强了硫甲醇 (SMX) 的生物降解,并减少了抗生素耐药性基因 (ARG). 这种综合方法为减轻废水处理中的抗生素化学和生物风险提供了一个有希望的策略.
科学领域:
- 环境微生物学环境微生物学
- 生物修复是一种生物修复.
- 抗微生物耐药性 (AMR) 是一种
背景情况:
- 在抗生素治疗期间抗菌素耐药性 (AMR) 的演变是一个重大问题.
- 缺乏有效的策略来缓解抗生素的化学和生物风险.
- 硫甲醇 (SMX) 是一种广泛使用的抗生素,具有环境持久性和耐药性影响.
研究的目的:
- 研究微空气和电刺激对SMX生物降解的联合影响.
- 了解这种联合调控对抗生素耐药性基因 (ARG) 的影响.
- 探索增强SMX降解和ARG缓解的潜在机制.
主要方法:
- 将微空气与电刺激结合起来,以调节微生物社区的氧化还原代谢.
- 分析SMX生物降解率和识别降解产品.
- 量化ARG和相关微生物基因的丰度和流动性的变化.
主要成果:
- 与无氧条件相比,微空气和电刺激的联合显著增加了SMX生物降解率.
- SMX被降解为较少有害的产品 (SA,p-AP),降低了风险系数.
- 观察到参与能量生成和电子转移的基因的丰富,ARG (例如,sul2) 和它们的移动性显著减少.
结论:
- 微空气与电刺激相结合,是增强SMX生物降解的有效策略.
- 这种方法通过减少选择性压力,成功地减轻了抗生素耐药性基因.
- 这些发现为生物修复机制提供了新的见解,并为管理抗生素风险提供了实际解决方案.
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